Could early biologics prevent disease?

Could successful (mitochondrial) networking help prevent Huntington's disease?

Polyglutamine expansions in huntingtin (Htt) are known to cause the profound neurodegenerative disorder, Huntington's disease (HD). Mitochondrial dysfunction has long been implicated in the pathophysiology of HD, but the underlying mechanism remains obscure. An article by Costa et al in this months edition describes a smooth mechanistic cascade from the well-accepted upstream event that mutant ...

Islam with the internet could do much to prevent disease.

Could anti IL12/23 therapy replace anti-TNF biologics?

Biologic therapies improved dramatically the outcome of psoriatic arthritis and moderate to severe chronic plaque psoriasis. Anti-TNF agents were developed approximately one decade ago by rheumatologists and today represent one of the most effective classes of drugs in severe psoriasis resistant to 2 out of 3 "classic" systemic therapies (methotrexate, cyclosporine, and PUVA). Recent studies on...

What if we could prevent heart failure?

a r k a p D a e c o a d i i a c t fi At 40 years of age, American men and women have a 1 in 5 lifetime risk of the development of heart failure (HF); by the latest estimates, there are 5,700,000 people in the United States who already have a diagnosis of the disease. Moreover, by the year 2030, it is predicted that an additional 3 million Americans will have HF, representing an astounding 25% i...

Could antioxidant supplementation prevent pre-eclampsia?

Pre-eclampsia is a disorder characterised by pregnancy-induced hypertension and new-onset proteinuria occurring in the second half of pregnancy. Worldwide, approximately 2-3% of all pregnant women develop pre-eclampsia. The condition is a major cause of maternal and fetal morbidity and mortality. Abnormal placentation is an important predisposing factor for pre-eclampsia, while endothelial acti...